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A Thai boy made headlines last week when his dark brown eyes a vibrant blue due to a rare reaction to a Covid drug.

While his side effect was caused by medication that is not used in the US, millions of Americans take drugs that can cause similarly bizarre symptoms.

Some antipsychotic medications can leave sufferers with extremely painful erections that last hours, while drugs to treat Parkinson's have been linked to compulsive gambling.

These are some of the most bizarre symptoms:  




No medication is free of side effects which typically range from the innocuous fatigue to the life-threatening skin rash that causes burnt flesh to slough off in sheets


Skin sloughing off in sheets from antibiotics
Common antibiotic medications including sulfonamides, chloramphenicol, penicillins, and quinolones have been known to cause Toxic epidermal necrolysis (TEN) that causes damage to 30 percent of the skin. 

It strikes after a bad reaction to an antibiotic. 

The immune system sometimes views an antibiotic medicine entering the body as a foreign invader. This activates immune T cells which then attack what it perceives as harm.

Those misinformed T cells then start attacking cells in the skin's outermost layer called the epidermis, having mistakenly identified normal skin cells as being infected by an outside invader.

Those T cells then inflict damage on skin cells and causing tissue damage, resulting in the characteristic skin blistering and sloughing. 

The resulting rash, though rare and affecting around 2 million Americans annually - less than one percent of the population - is a serious medical emergency and heightens the patient's risk of dehydration and severe bacterial infection that could enter the blood, such as sepsis.




Toxic epidermal necrolysis is rare though often occurs due to a bad systemic reaction to common antibiotic drugs

It typically requires treatment in the hospital burn unit, where doctors cover the person in ointments and dressings to heal the skin and prevent life-threatening infection. 

It also requires IV fluids, as burn-like skin loss can lead to dangerous dehydration and electrolyte loss.

While the condition itself is rare, it is fatal about a quarter of the time.

The death rate due to TEN is estimated to be between 21 to 25 percent based on European cohorts from the 1990s and early 2000s. 

A similar death rate is harder to pin down in the US, though a 2018 retrospective study that looked at TEN cases across the US from January 1, 2000, and June 1, 2015, returned a mortality rate of 14 percent.

People over 70 and those with already weak immune systems are at the highest risk of contracting TEN, which down the line can lead to a wide range of health complications.

These can include corneal damage leading to pain in the eyes and fluid leakage, potentially leading to vision loss that requires surgery to prevent.

Endless erections from antipsychotics
Anti-psychotic medications including ziprasidone, sold under the name Geodon,  chlorpromazine, also known as Thorazine, and risperidone, marketed as Risperdal, have been blamed for causing over half of all cases of priapism, a prolonged and painful erection generally lasting four hours or more. 

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