Anti-Cancer Benefit Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant found in treating numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This study aimed to research the results of 5 various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The outcomes indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the highest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (aside from total flavonoids) and antioxidant capacity, when compared to conventional and ultrasound-assisted extractions. These data reveal that the usage of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application inside the nutraceutical and/or pharmaceutical industries.

Drying methods, solvents and extraction methods greatly modify the phytochemical compounds and biological activity from plant materials. The aims of the study would determine the effects of various drying methods, various solvents and extraction methods on the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root extracted from Vietnam. The results established that microwave drying was a highly effective method in eliminating water in terms of shortest drying time, lowest energy consumption as well as retention of phytochemical compounds and antioxidant capacity from the P. trimera root while methanol and microwave-assisted extraction were the best solvent and means for greatest extraction from the phytochemical compounds and antioxidant capacity from the P. trimera root. The findings out of this study allow retaining the very best amounts of phytochemical compounds and antioxidant capacity in the P. trimera root for potential application from the nutraceutical industry.


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