Anti-Cancer Benefit Of Xao Tam Phan Paramignya Trimera Methanol Root Extract On Human Breast Cancer

Xao tam phan (Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant used in the treatment of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This research aimed to look into the effects of 5 various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The outcomes indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (aside from total flavonoids) and antioxidant capacity, in comparison to conventional and ultrasound-assisted extractions. These data reveal that using methanol and microwave-assisted extraction are suggested for extraction of biologically active phytochemicals from P. trimera root for application within the nutraceutical and/or pharmaceutical industries.

Drying methods, solvents and extraction methods greatly impact the phytochemical compounds and biological activity from plant materials. The aims of this study could determine the consequences of drying methods, various solvents and extraction methods for the phytochemical compounds and antioxidant capacity from Xao tam phan (Paramignya trimera) root obtained from Vietnam. The final results demonstrated that microwave drying was a powerful method in removing water in terms of shortest drying time, lowest energy consumption and greatest retention of phytochemical compounds and antioxidant capacity through the P. trimera root while methanol and microwave-assisted extraction were the best solvent and way of greatest extraction in the phytochemical compounds and antioxidant capacity in the P. trimera root. The findings because of this study allow retaining the greatest amounts of phytochemical compounds and antioxidant capacity through the P. trimera root for potential application in the nutraceutical industry.


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